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The key celltype mediated by type I interferon-stimulated genes in systemic lupus erythematosus revealed by single-cell and bulk RNA- seq analysis

2024-12-24

Abstract excerpt

<title>Abstract</title> <p>Background Systemic lupus erythematosus (SLE) is a complex autoimmune disease. Type I interferon (IFN-I) is one of the key pathogenic mechanisms, and overexpression of IFN-I leads to enhanced expression of its downstream interferon-stimulated genes (ISGs) and causes aberrant autoimmune responses. To date, a comprehensive assessment of ISG-mediated cell subsets in SLE remains lacking. M...

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Literature Corpus work
5557ea01-ffe9-5387-96fb-53d313835679
DOI
10.21203/rs.3.rs-5622204/v1
Open publication

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