Back to search

Article

Divergent Epigenetic and Transcriptomic Reprogramming of Monocyte Subpopulations in Systemic Lupus Erythematosus

2023-12-08

Abstract excerpt

Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by systemic inflammation involving various immune cell types. Monocytes, pivotal in promoting and regulating inflammation in SLE, differentiate from classical monocytes into intermediate monocytes and non-classical monocytes, assuming diverse roles. In this study, we investigated the epigenetic and transcriptomic profiles of these three mono...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
6065c547-1d07-5a9e-9592-59baa61bc308
DOI
10.1101/2023.12.07.570725
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Divergent Epigenetic and Transcriptomic Reprogramming of Monocyte Subpopulations in Systemic Lupus ErythematosusDOI 10.1101/2023.12.07.570725
Disease activity drives divergent epigenetic and transcriptomic reprogramming of monocyte subpopulations in systemic lupus erythematosusSemantic proximity
Single-cell RNA-seq reveals cell type–specific molecular and genetic associations to lupusSemantic proximity
Genome-Wide DNA Methylation Analysis of Systemic Lupus Erythematosus Reveals Persistent Hypomethylation of Interferon Genes and Compositional Changes to CD4+ T-cell PopulationsSemantic proximity
Single-cell gene expression patterns in lupus monocytes independently indicate disease activity, interferon and therapySemantic proximity
Distinct genome-wide DNA methylation and gene expression signatures in classical monocytes from African American patients with systemic sclerosisSemantic proximity
Epigenetic and transcriptomic reprogramming in monocytes of severe COVID-19 patients reflects alterations in myeloid differentiation and the influence of inflammatory cytokinesSemantic proximity
Epigenetic and transcriptomic reprogramming in monocytes of severe COVID-19 patients reflects alterations in myeloid differentiation and the influence of inflammatory cytokinesSemantic proximity
Multicohort Analysis of Publicly-available Monocyte Expression Data Identifies Gene Signatures to Accurately Monitor Subset-specific Changes in Human DiseasesSemantic proximity
Single-cell multimodal profiling of monocytes reveals diverse phenotypes and alterations linked to cardiovascular disease risksSemantic proximity
Transcriptomic studies unravel the molecular and cellular complexity of systemic lupus erythematosus: A reviewSemantic proximity
A Comprehensive Analysis of Type I Interferon Risk Gene Signatures in Systemic Lupus Erythematosus.Semantic proximity
Type I Interferon-Driven Monocyte Dysregulation and MAS-associated CD8 <sup>+</sup> T cells During Macrophage Activation SyndromeSemantic proximity
Select a neighboring publication to make it the new centre.