Article

Single-cell multi-omics analysis reveals IFN-driven alterations in T lymphocytes and natural killer cells in systemic lupus erythematosus

2021-04-29

Abstract excerpt

<h4>Background</h4> The characterisation of the peripheral immune system in the autoimmune disease systemic lupus erythematosus (SLE) at the single-cell level has been limited by the reduced sensitivity of current whole-transcriptomic technologies. Here we employ a targeted single-cell multi-omics approach, combining protein and mRNA quantification, to generate a high-resolution map of the T lymphocyte and natural...

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Literature Corpus work: bbe8bdb5-c28b-5a33-b31c-8291f2caa4bf
DOI: 10.1101/2021.04.27.21256106

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