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Lupus Immune Complexes Drive Distinct Pro-Inflammatory Monocyte and Macrophage Populations Independent of Type I Interferon

2026-01-22

Abstract excerpt

Systemic lupus erythematosus (SLE or lupus) is an autoimmune disease characterized by anti-nuclear antibody (ANA) production and inflammation, though the mechanisms by which ANAs induce inflammation and tissue injury are incompletely understood. Here, we identified distinct subsets of mononuclear phagocytes (MPs), including monocytes (Mo) and macrophages (MΦ), driven by lupus immune complex (IC), comprised of ANAs...

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Literature Corpus work
47d40ad0-b3a2-5f7e-b8d4-26780d3bdad8
DOI
10.64898/2026.01.21.700902
Open publication

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Lupus Immune Complexes Drive Distinct Pro-Inflammatory Monocyte and Macrophage Populations Independent of Type I InterferonDOI 10.64898/2026.01.21.700902
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