Article

Single-cell multi-omics analysis reveals IFN-driven alterations in T lymphocytes and natural killer cells in systemic lupus erythematosus

2022-05-12

Abstract excerpt

<h4>Background: </h4> The characterisation of the peripheral immune system in the autoimmune disease systemic lupus erythematosus (SLE) at the single-cell level has been limited by the reduced sensitivity of current whole-transcriptomic technologies. Here we employ a targeted single-cell multi-omics approach, combining protein and mRNA quantification, to generate a high-resolution map of the T lymphocyte and natur...

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Literature Corpus work: c80ff3d5-bd54-5808-a7b1-60f67251ecd5
DOI: 10.12688/wellcomeopenres.16883.2

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