Article

Immune Cells Harbor Their Own Microbiome-Derived Metabolome: A New Layer of Immunometabolic Regulation

2026-04-14

Abstract excerpt

Current models of microbiome–immune crosstalk center on extracellular receptor-mediated signaling, yet a critical observation challenges this paradigm: intracellular concentrations of gut-derived bacterial metabolites (GDBMs) in CD4⁺ T cells do not correlate with paired plasma levels, and it is intracellular — not circulating — GDBM burden that associates with metabolic pathway disruption and immune senescence. He...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3da0f3f5-bbae-5864-aba8-7c7d0546e029
DOI: 10.20944/preprints202604.0942.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Immune Cells Harbor Their Own Microbiome-Derived Metabolome: A New Layer of Immunometabolic RegulationDOI 10.20944/preprints202604.0942.v1Read

An atlas of transcriptomic changes in human immune cells driven by 364 endogenous and gut-microbiota-derived metabolitesSemantic proximity Read

Microenvironmental Ammonia Enhances T cell Exhaustion in Colorectal CancerSemantic proximity Read

Interleukin-21 Drives a Hypermetabolic State and CD4 <sup>+</sup> T Cell-associated Pathogenicity in Chronic Intestinal InflammationSemantic proximity Read

Nocturnal Melatonin Amplitude Collapse Is Associated with Age-Independent Convergence of Microbiome and Glymphatic BiomarkersSemantic proximity Read

Elevation of Gut-Derived p-Cresol During Spaceflight and its Effect on Drug Metabolism and Performance in AstronautsSemantic proximity Read

Pan-repository analysis reveals a drug-activating function of microbial bile acid conjugationSemantic proximity Read

Age-related microbiome metabolites alter RNA splicing and chromatin accessibility in the brainSemantic proximity Read

Metabolic targeting of regulatory T cells in oral squamous cell carcinoma: new horizons in immunotherapySemantic proximity Read

Evolutionary metabolic landscape from preneoplasia to invasive lung adenocarcinomaSemantic proximity Read

Dominant drivers of the human plasma metabolomeSemantic proximity Read

Natural Products in Prostate Cancer: Crosstalk among the Gut Microbiome, Androgen Receptor Signaling, and Epigenetic RegulationSemantic proximity Read

Aspartame Drives the Continuous Progression from MASLD to HCC: An Integrated AnalysisSemantic proximity Read