Article

Aspartame Drives the Continuous Progression from MASLD to HCC: An Integrated Analysis

2026-03-31

Abstract excerpt

<title>Abstract</title> <p>Background Aspartame (APM), a widely used sweetener, has been linked to cancers, yet its molecular impact on metabolic dysfunction-associated steatotic liver disease (MASLD) and subsequent hepatocellular carcinoma (HCC) remains undefined. We integrated network toxicology, bulk RNA-seq and docking to map the mechanism. Methods APM targets were retrieved from ChEMBL, STITCH and SwissTar...

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Literature Corpus work: 8cf02e5c-1873-5a35-99cb-fa91db6f220e
DOI: 10.21203/rs.3.rs-9171872/v1

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