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Evolutionary metabolic landscape from preneoplasia to invasive lung adenocarcinoma

10 Nov 2021

Abstract excerpt

Metabolic reprogramming evolves during cancer initiation and progression. However, thorough understanding of metabolic evolution from preneoplasia to lung adenocarcinoma (LUAD) is still limited. Here, we perform large-scale targeted metabolomics on resected lesions and plasma obtained from invasive LUAD and its precursors, and decipher the metabolic trajectories from atypical adenomatous hyperplasia (AAH) to...

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PMID: 34759281
DOI: 10.1038/s41467-021-26685-y

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