Article

Nocturnal Melatonin Amplitude Collapse Is Associated with Age-Independent Convergence of Microbiome and Glymphatic Biomarkers

2026-04-22

Abstract excerpt

<h4>Background: </h4> Circadian desynchronization is increasingly recognized as a transdiagnostic driver of metabolic, neurodegenerative, immune, and oncological pathology. Melatonin, acting primarily through the G-protein-coupled receptors MT1 (MTNR1A) and MT2 (MTNR1B), is the principal endocrine output of the circadian system and exerts pleiotropic oncostatic, antioxidant, and immunomodulatory effects. Whether d...

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Literature Corpus work: 1c2458f3-8d72-540f-9ef8-f47e3d326d1d
DOI: 10.20944/preprints202604.1532.v1

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