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Microenvironmental Ammonia Enhances T cell Exhaustion in Colorectal Cancer

2022-05-26

Abstract excerpt

<h4>ABSTRACT</h4> Effective therapies are lacking for patients with advanced colorectal cancer (CRC). The CRC tumor microenvironment has elevated metabolic waste products due to altered metabolism and proximity to the microbiota. The role of metabolite waste in tumor development, progression, and treatment resistance is unclear. We generated an autochthonous metastatic mouse model of CRC and unbiased multi-omic a...

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Literature Corpus work
f0821338-cb19-50a4-a183-552311ee97b4
DOI
10.1101/2022.05.25.493422
Open publication

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Microenvironmental Ammonia Enhances T cell Exhaustion in Colorectal CancerDOI 10.1101/2022.05.25.493422
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