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Metabolic targeting of regulatory T cells in oral squamous cell carcinoma: new horizons in immunotherapy

18 Dec 2024

Abstract excerpt

Oral squamous cell carcinoma (OSCC) is a prevalent oral malignancy, which poses significant health risks with a high mortality rate. Regulatory T cells (Tregs), characterized by their immunosuppressive capabilities, are intricately linked to OSCC progression and patient outcomes. The metabolic reprogramming of Tregs within the OSCC tumor microenvironment (TME) underpins their function, with key pathways such as...

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PMID: 39696340
DOI: 10.1186/s12943-024-02193-7

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