Article

Age-related microbiome metabolites alter RNA splicing and chromatin accessibility in the brain

2025-10-05

Abstract excerpt

The gut microbiome generates diverse metabolites that can enter the bloodstream and alter host biology, including brain function. Hundreds of physiologically relevant, gut-brain signaling molecules likely exist; however, there has been no systematic, high-throughput effort to identify and validate them. Here, we integrate computational, in vitro , and in vivo approaches to pinpoint microbiome-derived metabolites...

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Literature Corpus work: ae05c3b3-1fe6-5eda-b838-6011f7290404
DOI: 10.1101/2025.10.03.680371

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