Article

SVEP1 regulates GPCR-mediated vasoconstriction via integrin α9β1 and α4β1

2024-01-31

Abstract excerpt

<h4>Background: </h4> and purpose Vascular tone is regulated by the relative contractile state of vascular smooth muscle cells (VSMCs). Several integrins directly modulate VSMC contraction by regulating calcium influx through L-type voltage-gated Ca2+ channels (VGCCs). Genetic variants in ITGA9, which encodes the α9 subunit of integrin α9β1, and SVEP1, a ligand for integrin α9β1, associate with elevated blood pres...

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Literature Corpus work: cb0c41b0-79f3-5b66-8c29-100adcc1bc0a
DOI: 10.22541/au.170668556.68406410/v1

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