Transcription factors: key regulatory targets of vascular smooth muscle cell in atherosclerosis.

doi:10.1186/s10020-022-00586-2

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Article

Transcription factors: key regulatory targets of vascular smooth muscle cell in atherosclerosis.

Molecular medicine (Cambridge, Mass.) - 5 Jan 2023

Jiang Yu, Qian Hai-Yan

Abstract excerpt

Atherosclerosis (AS), leading to gradual occlusion of the arterial lumen, refers to the accumulation of lipids and inflammatory debris in the arterial wall. Despite therapeutic advances over past decades including intervention or surgery, atherosclerosis is still the most common cause of cardiovascular diseases and the main mechanism of death and disability worldwide. Vascular smooth muscle cells (VSMCs) play an...

Topics

Humans
Muscle, Smooth, Vascular
Transcription Factors
Cell Proliferation
Atherosclerosis
Gene Expression Regulation
Myocytes, Smooth Muscle
Cells, Cultured
Phenotype

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Identifiers

PMID: 36604627
DOI: 10.1186/s10020-022-00586-2
PMCID: PMC9817296

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