Article
Functional investigation of the coronary artery disease gene SVEP1.
Basic research in cardiology - 13 Nov 2020
Winkler Michael J, Müller Philipp, Sharifi Amin M, Wobst Jana, Winter Hanna, Mokry Michal, Ma Lijiang, van der Laan Sander W, Pang Shichao, Miritsch Benedikt, Hinterdobler Julia, Werner Julia, Stiller Barbara, Güldener Ulrich, Webb Tom R, Asselbergs Folkert W, Björkegren Johan L M, Maegdefessel Lars, Schunkert Heribert, Sager Hendrik B, Kessler Thorsten
Abstract excerpt
A missense variant of the sushi, von Willebrand factor type A, EGF and pentraxin domain containing protein 1 (SVEP1) is genome-wide significantly associated with coronary artery disease. The mechanisms how SVEP1 impacts atherosclerosis are not known. We found endothelial cells (EC) and vascular smooth muscle cells to represent the major cellular source of SVEP1 in plaques. Plaques were larger in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.