Article
Generation and validation of a Myh11Dre-Spp1Cre intersectional mouse model for lineage tracing of disease-associated smooth muscle cell states.
Vascular pharmacology - 1 Sept 2026
Tu Yuchi, Ishimwe Nestor, Ofori Benedict, Aherrahrou Redouane, Dong Kunzhe, Long Xiaochun
Abstract excerpt
BACKGROUND: Phenotypic modulation of vascular smooth muscle cells (VSMCs) is a hallmark of vascular remodeling and cardiovascular disease. Recent lineage-tracing and single-cell transcriptomic studies have identified secreted phosphoprotein 1 (SPP1) as a prominent marker associated with disease-associated VSMC states, particularly those linked to fibrotic remodeling and vascular calcification. However, the...
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- Animals
- Cell Lineage
- Myocytes, Smooth Muscle
- Muscle, Smooth, Vascular
- Phenotype
- Integrases