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Selection for or against Escape from Nonsense Mediated Decay is a Novel Signature for the Detection of Cancer Genes

2021-04-13

Abstract excerpt

Escape from nonsense mediated decay (NMD-) can produce activated or inactivated gene products, and bias in rates of escape can identify functionally important genes in germline disease. We hypothesized that the same would be true of cancer genes, and tested for NMD- bias within The Cancer Genome Atlas pan-cancer somatic mutation dataset. We identify 29 genes that show significantly elevated or suppressed rates of...

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Literature Corpus work
781aa9dc-9df9-5960-ae45-b3fff58d690d
DOI
10.1101/2021.04.12.439236
Open publication

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Selection for or against Escape from Nonsense Mediated Decay is a Novel Signature for the Detection of Cancer GenesDOI 10.1101/2021.04.12.439236
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