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Revealing the contribution of somatic gene mutations to shaping tumor immune microenvironment.

Briefings in bioinformatics - 13 May 2022

Xu Liwen, Zhu Shiwei, Lan Yujia, Yan Min, Jiang Zedong, Zhu Jiali, Liao Gaoming, Ping Yanyan, Xu Jinyuan, Pang Bo, Zhang Yunpeng, Xiao Yun, Li Xia

Abstract excerpt

Interaction between tumor cells and immune cells determined highly heterogeneous microenvironments across patients, leading to substantial variation in clinical benefits from immunotherapy. Somatic gene mutations were found not only to elicit adaptive immunity but also to influence the composition of tumor immune microenvironment and various processes of antitumor immunity. However, due to an incomplete view of...

Topics

Biomarkers, Tumor
CD8-Positive T-Lymphocytes
Humans
Immunotherapy
Mutation
Neoplasms
Tumor Microenvironment

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 35229870
DOI: 10.1093/bib/bbac064

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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