Article
Immunogenomic pan-cancer landscape reveals immune escape mechanisms and immunoediting histories.
Scientific reports - 3 Aug 2021
Mizuno Shinichi, Yamaguchi Rui, Hasegawa Takanori, Hayashi Shuto, Fujita Masashi, Zhang Fan, Koh Youngil, Lee Su-Yeon, Yoon Sung-Soo, Shimizu Eigo, Komura Mitsuhiro, Fujimoto Akihiro, Nagai Momoko, Kato Mamoru, Liang Han, Miyano Satoru, Zhang Zemin, Nakagawa Hidewaki, Imoto Seiya
Abstract excerpt
Immune reactions in the tumor microenvironment are an important hallmark of cancer, and emerging immune therapies have been proven effective against several types of cancers. To investigate cancer genome-immune interactions and the role of immunoediting or immune escape mechanisms in cancer development, we analyzed 2834 whole genome and RNA sequencing datasets across 31 distinct tumor types with respect to key...
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