Article

Large-scale imputation models for multi-ancestry proteome-wide association analysis

2023-10-09

Abstract excerpt

Proteome-wide association studies (PWAS) decode the intricate proteomic landscape of biological mechanisms for complex diseases. Traditional PWAS model training relies heavily on individual-level reference proteomes, restricting its capacity to harness the emerging summary-level protein quantitative trait loci (pQTL) data in the public domain. Here we introduced BLISS, a novel framework to train protein imputation...

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Literature Corpus work: 310c4179-a05e-5291-9361-482bdbb9d94d
DOI: 10.1101/2023.10.05.561120

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