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Multi-Omics Integration Improves Polygenic Risk Prediction for Lipid Traits: A Multi-Ancestry Study in UK Biobank.

Genes - 22 Jul 2026

Shan Nayang, Qiu Yafang, Hou Lin, Wang Zuoheng

Abstract excerpt

Background: Polygenic risk scores (PRS) have proven valuable for disease risk prediction, but their predictive utility often remains limited because human traits result from complex interactions between environmental and genetic factors. Blood lipid levels are heritable and clinically important risk factors for cardiovascular disease, yet it remains unclear whether multi-omics integration can enhance lipid trait...

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PMID: 42510880
DOI: 10.3390/genes17070840
PMCID: PMC13409989

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