Article

The drug-induced phenotypic landscape of colorectal cancer organoids

2019-06-07

Abstract excerpt

Patient derived organoids resemble the biology of tissues and tumors, enabling ex vivo modeling of human diseases from primary patient samples. Organoids can be used as models for drug discovery and are being explored to guide clinical decision making. Patient derived organoids can have heterogeneous morphologies with unclear biological causes and relationship to treatment response. Here, we used high-throughput,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: eaed0280-edc7-5713-ac26-571cf99f36c5
DOI: 10.1101/660993

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The drug-induced phenotypic landscape of colorectal cancer organoidsDOI 10.1101/660993Read

The drug-induced phenotypic landscape of colorectal cancer organoids.Semantic proximity Read

Ex vivo modeling of morphological, molecular and pharmacological tumor heterogeneity of metastatic colorectal cancerSemantic proximity Read

Multi-omics, organoid-based modeling reveals an SRC/mTOR-dependent fetal-like stem cell trajectory in colorectal cancerSemantic proximity Read

Modeling colorectal cancer: A bio‐resource of 50 patient‐derived organoid linesSemantic proximity Read

Deciphering spatial heterogeneity of patient-derived organoids of colorectal tumors for drug discoverySemantic proximity Read

Establishment and Characterization of 21 Human Colorectal Cancer Patient-Derived OrganoidsSemantic proximity Read

Mimicking Tumor Cell Heterogeneity of Colorectal Cancer in a Patient-derived Organoid-Fibroblast ModelSemantic proximity Read

3D imaging of colorectal cancer organoids identifies responses to Tankyrase inhibitorsSemantic proximity Read

3D imaging of colorectal cancer organoids identifies responses to Tankyrase inhibitorsSemantic proximity Read

From Genomic Alterations to Functional Tumor Biology: Integrating Organoids and Organ-on-a-Chip in Colorectal Cancer.Semantic proximity Read

Ex Vivo Organoid Cultures Reveal the Importance of the Tumor Microenvironment for Maintenance of Colorectal Cancer Stem CellsSemantic proximity Read

A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis.Semantic proximity Read