Article
The drug-induced phenotypic landscape of colorectal cancer organoids.
Nature communications - 6 Jun 2022
Betge Johannes, Rindtorff Niklas, Sauer Jan, Rauscher Benedikt, Dingert Clara, Gaitantzi Haristi, Herweck Frank, Srour-Mhanna Kauthar, Miersch Thilo, Valentini Erica, Boonekamp Kim E, Hauber Veronika, Gutting Tobias, Frank Larissa, Belle Sebastian, Gaiser Timo, Buchholz Inga, Jesenofsky Ralf, Härtel Nicolai, Zhan Tianzuo, Fischer Bernd, Breitkopf-Heinlein Katja, Burgermeister Elke, Ebert Matthias P, Boutros Michael
Abstract excerpt
Patient-derived organoids resemble the biology of tissues and tumors, enabling ex vivo modeling of human diseases. They have heterogeneous morphologies with unclear biological causes and relationship to treatment response. Here, we use high-throughput, image-based profiling to quantify phenotypes of over 5 million individual colorectal cancer organoids after treatment with >500 small molecules. Integration of...
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