Article

Multi-omics, organoid-based modeling reveals an SRC/mTOR-dependent fetal-like stem cell trajectory in colorectal cancer

2026-07-03

Abstract excerpt

<h4>Background</h4> Single-cell atlases have described diverse stem cell states in colorectal cancer (CRC), however, the overarching trajectories of those states and the underlying functional mechanisms, including their relevance for drug sensitivity, need better understanding. <h4>Methods</h4> We established 64 patient-derived organoids from microsatellite-stable colorectal cancers, characterized their transcri...

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Literature Corpus work: 5c44a4f4-e82e-5829-ba1d-ec9a14ae47bd
DOI: 10.64898/2026.07.03.735750

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