Article

Hematopoietic Tet2 inactivation enhances the response to checkpoint blockade immunotherapy

2024-09-11

Abstract excerpt

<h4>ABSTRACT</h4> Somatic mutations inactivating TET2 are among the most common drivers of clonal hematopoiesis (CH). While TET2 inactivation is associated with monocyte-derived inflammation and improved chimeric antigen-receptor-T cell function, its impact on immunotherapy response is unknown. In our mouse model, hematopoietic Tet2 mutation enhanced immune checkpoint blockade (ICB) response. Enhanced ICB respo...

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Literature Corpus work: 3cf27de1-40c1-5318-8686-965f141f4468
DOI: 10.1101/2024.09.09.612140

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