Response to Immune Checkpoint Blockade Is Enhanced in the Presence of Hematopoietic TET2 Inactivation.

doi:10.1158/0008-5472.CAN-24-3329

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Article

Response to Immune Checkpoint Blockade Is Enhanced in the Presence of Hematopoietic TET2 Inactivation.

Cancer research - 16 Feb 2026

Rondeau Vincent, Bansal Suraj, Buttigieg Marco M, Zeng Andy G X, Chan Darryl Y, Chan-Seng-Yue Michelle, Jin Liqing, McLeod Jessica, Kates Meghan, Donato Elisa, Stelmach Patrick, Vlasschaert Caitlyn, Yang Yitong, Gupta Aarushi, Genta Sofia, Sanz-Garcia Enrique, Shlush Liran, Ribeiro Mauricio, Butler Marcus O, Abelson Sagi, Minden Mark D, Saibil Samuel D, Chan Steven M, Rauh Michael J, Trumpp Andreas, Dick John E, Vanner Robert J

Abstract excerpt

Somatic mutations inactivating Tet methylcytosine dioxygenase 2 (TET2) are among the most common drivers of clonal hematopoiesis (CH). TET2 inactivation is associated with monocyte-derived inflammation and improved chimeric antigen receptor T-cell function, suggesting that it might also affect immunotherapy response. In this study, we found that hematopoietic Tet2 mutation in mouse models enhanced the immune...

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PMID: 41218172
DOI: 10.1158/0008-5472.CAN-24-3329

Genes

TET2
CD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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Response to Immune Checkpoint Blockade Is Enhanced in the Presence of Hematopoietic TET2 Inactivation.PMID 41218172Read ↗

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