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Article

Tumor-Infiltrating Clonal Hematopoiesis

23 Apr 2025

Abstract excerpt

Background Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related condition associated with increased mortality among patients with cancer. CHIP mutations with high variant-allele frequencies can be detected in tumors, a phenomenon we term tumor-infiltrating clonal hematopoiesis (TI-CH). The frequency of TI-CH and its effect on tumor evolution are unclear. Methods We characterized CHIP and TI-CH...

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PMID: 40267425
DOI: 10.1056/nejmoa2413361

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