Article
B-cell tumor development in Tet2-deficient mice.
Blood advances - 27 Mar 2018
Mouly Enguerran, Ghamlouch Hussein, Della-Valle Veronique, Scourzic Laurianne, Quivoron Cyril, Roos-Weil Damien, Pawlikowska Patrycja, Saada Véronique, Diop M'Boyba K, Lopez Cécile K, Fontenay Michaela, Dessen Philippe, Touw Ivo P, Mercher Thomas, Aoufouchi Said, Bernard Olivier A
Abstract excerpt
The TET2 gene encodes an α-ketoglutarate-dependent dioxygenase able to oxidize 5-methylcytosine into 5-hydroxymethylcytosine, which is a step toward active DNA demethylation. TET2 is frequently mutated in myeloid malignancies but also in B- and T-cell malignancies. TET2 somatic mutations are also identified in healthy elderly individuals with clonal hematopoiesis. Tet2-deficient mouse models showed widespread...
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