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Article

Tet2 deficiency in immune cells exacerbates tumor progression by increasing angiogenesis in a lung cancer model

19 Oct 2021

Abstract excerpt

Immune cells harboring somatic mutations reportedly infiltrate cancer tissues in patients with solid cancers and accompanying clonal hematopoiesis. Loss-of-function TET2 mutations are frequently observed in clonal hematopoiesis in solid cancers. Here, using a mouse lung cancer model, we evaluated the activity of Tet2-deficient immune cells in tumor tissues. Myeloid-specific Tet2 deficiency enhanced tumor growth...

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PMID: 34657351
DOI: 10.1111/cas.15165

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