TOX2 coordinates with TET2 to positively regulate central memory differentiation in human CAR T cells

Abstract excerpt

Chimeric antigen receptor (CAR) T cell therapy is used in treating human hematological malignancies, but its efficacy is limited by T cell exhaustion (T EX ). T EX arises at the expense of central memory T cells (T CM ), which exhibit robust antitumor efficacy. Reduction of the TET2 gene led to increased T CM differentiation in a patient with leukemia who experienced a complete remission. We show that loss of...

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