Article

<i>TET2</i> -mutant clonal hematopoiesis prevents T-cell exhaustion and suppresses cancer metastasis

2026-03-08

Abstract excerpt

<h4>ABSTRACT</h4> Clonal hematopoiesis (CH) is widely regarded as a risk factor for age-associated disease, yet its influence on solid tumor progression remains poorly understood. Here, we uncover an unexpected tumor-suppressive role for TET2 -mutant CH in solid tumors. Through an analysis of over 16,000 cancer patients, we demonstrate that TET2 mutations are associated with a significant reduction in metastati...

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Literature Corpus work: 383a831e-f0d9-5efb-a9cc-28ed2df5da5d
DOI: 10.64898/2026.03.05.709727

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