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Article

Tet2 deficiency drives age-related heterogeneous progression of myeloid neoplasms through epigenetic-immune microenvironment imbalance.

Journal of translational medicine - 8 Sept 2026

Chen Yanxi, Yu Li, Yang Rui, Chen Pengjie, Zeng Wen, Li Zihan, Wang Yanting, Xu Yonggang, Yang Xiupeng

Abstract excerpt

BACKGROUND: Tet2 dysfunction drives myeloid neoplasm initiation and progression, yet the mechanisms underlying disease heterogeneity, age-dependent progression and immune microenvironment perturbation remain poorly understood. This study aimed to establish a hematopoietic specific Tet2 conditional knockout mouse model to elucidate these core mechanisms and recapitulate clinical features of Tet2 mutated myeloid...

Read the complete abstract on PubMed

Topics

Animals
Proto-Oncogene Proteins
Dioxygenases
DNA-Binding Proteins
Epigenesis, Genetic
Disease Progression

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Tumor Microenvironment

Aging

Mice, Inbred C57BL

Phenotype

Mice, Knockout

Female

Source

Open in PubMed Open full text

Identifiers

PMID: 42717353
DOI: 10.1186/s12967-026-08835-2
PMCID: PMC13555968

Genes

CCL17
CCL22
CCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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