Article

Leveraging High-Throughput Proteomics and AI-Based Protein Folding to Accelerate VAV1 Molecular Glue Discovery

2026-03-10

Abstract excerpt

<title>Abstract</title> <p>This study reports the discovery and characterization of novel CRBN molecular glues that selectively induce the proteasomal degradation of the hematopoietic-specific signaling protein VAV1, a key target in hematological malignancies and autoimmune diseases. Utilizing unbiased global proteomics, we identified phenyl-glutarimide derivatives NGT-201-12, as effective VAV1 degraders, with it...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3cea394f-acb0-5421-96c5-4e52d19368ba
DOI: 10.21203/rs.3.rs-6712113/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Leveraging High-Throughput Proteomics and AI-Based Protein Folding to Accelerate VAV1 Molecular Glue DiscoveryDOI 10.21203/rs.3.rs-6712113/v1Read

Leveraging High-Throughput Proteomics and AI-Based Protein Folding to Accelerate VAV1 Molecular Glue DiscoverySemantic proximity Read

Generative AI Framework SynGlue for the Rational Design of Clinically relevant Protein DegradersSemantic proximity Read

Design of a First-in-Class homoPROTAC to Induce ICP0 Degradation in Human Herpes Simplex Virus 1Semantic proximity Read

Integrated proteomic screening reveals design principles of CRBN molecular glue degradersSemantic proximity Read

Shifting Beyond Classical Drug Synergy in Combinatorial Therapy through Solubility AlterationsSemantic proximity Read

Rules for hardening influenza A virus liquid condensatesSemantic proximity Read

Mining the CRBN Target Space Redefines Rules for Molecular Glue-induced Neosubstrate RecognitionSemantic proximity Read

A general computational design strategy for stabilizing viral class I fusion proteinsSemantic proximity Read

Covalent anti-HIV compound that induces HIV-1 capsid multimerization and degradation decomposes the viral coreSemantic proximity Read

Design of a Cereblon construct for crystallographic and biophysical studies of protein degradersSemantic proximity Read

More than an attachment module: covalent inhibitor warheads influence BTK dynamics and functionSemantic proximity Read

Allosteric activation of VCP, a AAA unfoldase, by small molecule mimicrySemantic proximity Read