Mining the CRBN Target Space Redefines Rules for Molecular Glue-induced Neosubstrate Recognition

Abstract excerpt

The CRL4 CRBN ubiquitin ligase is leveraged by molecular glue degraders, small molecules that reprogram ligase specificity to induce degradation of clinically relevant neosubstrate proteins. Known CRBN neosubstrates share a generalizable β-hairpin G-loop recognition motif, yet systematic exploration of the CRBN target landscape is still pending. Through computational mining of the human proteome using structure-b...

Topics

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• CAR-T cell therapy research
• CRISPR and Genetic Engineering
• Multiple Myeloma Research and Treatments
• Peptidase Inhibition and Analysis
• Protein Degradation and Inhibitors
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

92977c3a-cbcc-5eaf-8e51-acc68c646345

DOI

10.1101/2024.10.07.616933