Article

Allosteric activation of VCP, a AAA unfoldase, by small molecule mimicry

2023-10-02

Abstract excerpt

The loss of function of AAA (ATPases associated with diverse cellular activities) mechanoenzymes has been linked to diseases, and small molecules that activate these proteins can be powerful tools to probe mechanisms and test therapeutic hypotheses. Unlike chemical inhibitors that can bind a single conformational state to block enzyme activity, activator binding must be permissive to different conformational state...

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Literature Corpus work: 68c45f36-f741-5940-9b2e-ce051c68ec89
DOI: 10.1101/2023.10.02.560478

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