Article

More than an attachment module: covalent inhibitor warheads influence BTK dynamics and function

2026-05-08

Abstract excerpt

<h4>ABSTRACT</h4> Covalent inhibitors are rapidly becoming the standard of care for treatment of a range of disease states. Covalent inhibitors bind irreversibly to their target using a reactive electrophile (or ‘warhead’). Acrylamide and 2-butynamide are the most commonly used cysteine targeting electrophiles. These warheads are chosen for their efficient and selective modification of the protein and are presume...

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Literature Corpus work: 4cc3690d-0683-57b5-9ede-685bff3729c0
DOI: 10.64898/2026.05.07.723540

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