Article

Shifting Beyond Classical Drug Synergy in Combinatorial Therapy through Solubility Alterations

2025-08-22

Abstract excerpt

<title>Abstract</title> <p>Acute myeloid leukemia (AML) remains a formidable clinical challenge due to genetic heterogeneity, high relapse rates, and toxicities associated with conventional chemotherapies. Rationally designed drug combinations offer improved efficacy, yet their selection is often empirical and lacks molecular mechanistic understanding. Here, we present our workflow for Combinatorial Proteome Inte...

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Literature Corpus work: ef0645dd-57e0-56b4-a33a-71730fe547bf
DOI: 10.21203/rs.3.rs-7291305/v1

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