Back to search

Article

Design of a First-in-Class homoPROTAC to Induce ICP0 Degradation in Human Herpes Simplex Virus 1

2025-07-11

Abstract excerpt

<h4>Background: </h4> /Objectives: Human Herpes Simplex Virus 1 (HSV-1) is a pervasive pathogen that establishes lifelong latent infections, and the emergence of drug resistance necessitates novel therapeutic strategies. This study puts forth a first-in-class antiviral concept: a bivalent degrader designed to force the virus to destroy its own critical machinery. <h4>Methods:</h4> We target the viral E3 ubiquitin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
7be64de6-f920-5e3c-9a44-f3f0117467af
DOI
10.20944/preprints202507.0791.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Design of a First-in-Class homoPROTAC to Induce ICP0 Degradation in Human Herpes Simplex Virus 1DOI 10.20944/preprints202507.0791.v1
Large Subunit of the Human Herpes Simplex Virus Terminase as a Promising Target in Design of Anti-Herpesvirus AgentsSemantic proximity
The three-component helicase/primase complex of herpes simplex virus-1Semantic proximity
Structural insights into inhibition mechanism of the helicase-primase complex from human herpesvirus 1Semantic proximity
Systematic Validation of AlphaFold-Predicted Interactomes with LUCIASemantic proximity
Leveraging High-Throughput Proteomics and AI-Based Protein Folding to Accelerate VAV1 Molecular Glue DiscoverySemantic proximity
Inhibiting Early-Stage Events in HIV-1 Replication by Small-Molecule Targeting of the HIV-1 CapsidSemantic proximity
20S Proteasome Inhibition: Designing Noncovalent Linear Peptide Mimics of the Natural Product TMC‐95ASemantic proximity
Combating Antiviral Drug Resistance: A Multipronged Strategy.Semantic proximity
Pressurized DNA state inside herpes capsids—A novel antiviral targetSemantic proximity
Discovery of an Antiviral PROTAC Targeting the SARS-CoV-2 Main Protease Using an Allosteric WarheadSemantic proximity
Viral Nuclease Inhibitors: Small molecule disruptors of the UL12 alkaline nuclease display broad anti-herpes virus activitySemantic proximity
Leveraging High-Throughput Proteomics and AI-Based Protein Folding to Accelerate VAV1 Molecular Glue DiscoverySemantic proximity
Select a neighboring publication to make it the new centre.