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Article

Lifestyle, genetic risk, plasma pTau217, and incident cognitive impairment in WRAP.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Aug 2025

Studer Rachel L, Cody Karly A, Oomens Julie E, Reyes Ramiro Eduardo Rea, Chin Nathaniel A, Mueller Kimberly D, Hermann Bruce P, Wilson Rachael E, Langhough Rebecca E, Jonaitis Erin M, Johnson Sterling C

Abstract excerpt

INTRODUCTION: Whether lifestyle-based dementia risk in midlife impacts risk of incident cognitive impairment (ICI) in the presence of apolipoprotein E (APOE) ε4 allele or plasma pTau217 remains unknown. METHODS: In initially cognitively unimpaired participants (N = 1088; baseline age, M(SD) = 57.8(6.5) years) from the Wisconsin Registry for Alzheimer's Prevention (WRAP), we investigated the relationship between...

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PMID: 40799136
DOI: 10.1002/alz.70573
PMCID: PMC12344448

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APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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