Article

Relationship between BrainAge Polygenetic Risk Score and plasma biomarkers in the A4/LEARN studies

2025-07-10

Abstract excerpt

<h4>Background and Objectives</h4> To examine the association between genetic predisposition to accelerated brain aging—measured with polygenic risk scores (PRS) derived from BrainAge models—and plasma biomarkers of Alzheimer’s disease (AD), with attention to age and sex-specific effects. <h4>Methods</h4> We analyzed 1994 cognitively unimpaired participants from the A4/LEARN studies (71.5±4.8 years; 41% male). W...

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Literature Corpus work: 1b4eb9ff-1fa7-55e6-922f-b6ab6d2733bc
DOI: 10.1101/2025.07.07.25331010

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