Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of Repair Mechanisms following an Induced Double-Strand Break Uncovers Recessive Deleterious Alleles in the Candida albicans Diploid Genome.

mBio - 11 Oct 2016

Feri Adeline, Loll-Krippleber Raphaël, Commere Pierre-Henri, Maufrais Corinne, Sertour Natacha, Schwartz Katja, Sherlock Gavin, Bougnoux Marie-Elisabeth, d'Enfert Christophe, Legrand Mélanie

Abstract excerpt

The diploid genome of the yeast Candida albicans is highly plastic, exhibiting frequent loss-of-heterozygosity (LOH) events. To provide a deeper understanding of the mechanisms leading to LOH, we investigated the repair of a unique DNA double-strand break (DSB) in the laboratory C. albicans SC5314 strain using the I-SceI meganuclease. Upon I-SceI induction, we detected a strong increase in the frequency of LOH...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Candida albicans

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Breaks, Double-Stranded

Share to DNA Repair

Share to Genome, Fungal

Share to Loss of Heterozygosity

Share to Polymorphism, Single Nucleotide

Share to Recombination, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 27729506
DOI: 10.1128/mBio.01109-16
PMCID: PMC5061868

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of Repair Mechanisms following an Induced Double-Strand Break Uncovers Recessive Deleterious Alleles in the Candida albicans Diploid Genome.PMID 27729506Read ↗

The Genome of the Human Pathogen <i>Candida albicans</i> is Shaped by Mutation and Cryptic Sexual RecombinationSemantic proximity Read ↗

The Impact of Gene Dosage and Heterozygosity on the Diploid Pathobiont Candida albicansSemantic proximity Read ↗

Genome plasticity in Candida albicans: A cutting-edge strategy for evolution, adaptation, and survivalSemantic proximity Read ↗

A Global Analysis of Mutations Accompanying Microevolution in the Heterozygous Diploid Pathogen <i>Candida albicans</i>Semantic proximity Read ↗

Factors that influence bidirectional long-tract homozygosis due to double-strand break repair in Candida albicans.Semantic proximity Read ↗

Genome-wide single-nucleotide polymorphism map for Candida albicans.Semantic proximity Read ↗

Global analysis of mutations driving microevolution of a heterozygous diploid fungal pathogen.Semantic proximity Read ↗

Host-Induced Genome Instability Rapidly Generates Phenotypic Variation across Candida albicans Strains and Ploidy States.Semantic proximity Read ↗

Host Defense Mechanisms Induce Genome Instability Leading to Rapid Evolution in an Opportunistic Fungal PathogenSemantic proximity Read ↗

The Genome of the Human Pathogen Candida albicans Is Shaped by Mutation and Cryptic Sexual RecombinationSemantic proximity Read ↗

The diploid genome sequence of <i>Candida albicans</i>Semantic proximity Read ↗

Targeted loss of heterozygosity in <i>Candida albicans</i> using CRISPR-Cas9Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.