Article
Accelerated functional brain aging in pre-clinical familial Alzheimer's disease.
Nature communications - 9 Sept 2021
Gonneaud Julie, Baria Alex T, Pichet Binette Alexa, Gordon Brian A, Chhatwal Jasmeer P, Cruchaga Carlos, Jucker Mathias, Levin Johannes, Salloway Stephen, Farlow Martin, Gauthier Serge, Benzinger Tammie L S, Morris John C, Bateman Randall J, Breitner John C S, Poirier Judes, Vachon-Presseau Etienne, Villeneuve Sylvia
Abstract excerpt
Resting state functional connectivity (rs-fMRI) is impaired early in persons who subsequently develop Alzheimer's disease (AD) dementia. This impairment may be leveraged to aid investigation of the pre-clinical phase of AD. We developed a model that predicts brain age from resting state (rs)-fMRI data, and assessed whether genetic determinants of AD, as well as beta-amyloid (Aβ) pathology, can accelerate brain...
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