Connectome-based predictive modeling of brain pathology and cognition in autosomal dominant Alzheimer's disease.

doi:10.1002/alz.70061

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Article

Connectome-based predictive modeling of brain pathology and cognition in autosomal dominant Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Mar 2025

Tripathi Vaibhav, Fox-Fuller Joshua, Malotaux Vincent, Baena Ana, Felix Nikole Bonillas, Alvarez Sergio, Aguillon David, Lopera Francisco, Somers David C, Quiroz Yakeel T

Abstract excerpt

INTRODUCTION: Autosomal dominant Alzheimer's disease (ADAD) through genetic mutations can result in near complete expression of the disease. Tracking AD pathology development in an ADAD cohort of Presenilin-1 (PSEN1) E280A carriers' mutation has allowed us to observe incipient tau tangles accumulation as early as 6 years prior to symptom onset. METHODS: Resting-state functional magnetic resonance imaging (fMRI)...

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