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Article

Multimodal Imaging in Rat Model Recapitulates Alzheimer's Disease Biomarkers Abnormalities.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 13 Dec 2017

Parent Maxime J, Zimmer Eduardo R, Shin Monica, Kang Min Su, Fonov Vladimir S, Mathieu Axel, Aliaga Antonio, Kostikov Alexey, Do Carmo Sonia, Dea Doris, Poirier Judes, Soucy Jean-Paul, Gauthier Serge, Cuello A Claudio, Rosa-Neto Pedro

Abstract excerpt

Imaging biomarkers are frequently proposed as endpoints for clinical trials targeting brain amyloidosis in Alzheimer's disease (AD); however, the specific impact of amyloid-β (Aβ) aggregation on biomarker abnormalities remains elusive in AD. Using the McGill-R-Thy1-APP transgenic rat as a model of selective Aβ pathology, we characterized the longitudinal progression of abnormalities in biomarkers commonly used in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29097597
DOI: 10.1523/JNEUROSCI.1346-17.2017
PMCID: PMC5729194

Genes

APP

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