Article

Connectome-based predictive modeling of brain pathology and cognition in Autosomal Dominant Alzheimer’s Disease

2024-09-03

Abstract excerpt

<h4>INTRODUCTION</h4> Autosomal Dominant Alzheimer’s Disease (ADAD) through genetic mutations can result in near complete expression of the disease. Tracking AD pathology development in an ADAD cohort of Presenilin-1 ( PSEN1) E280A carriers’ mutation has allowed us to observe incipient tau tangles accumulation as early as 6 years prior to symptom onset. <h4>METHODS</h4> Resting-state functional Magnetic Resonance...

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Literature Corpus work: 15a209bb-ff96-5063-b1b7-5d3c11f7184e
DOI: 10.1101/2024.09.01.24312913

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