Article

Human neurons lacking amyloid precursor protein exhibit cholesterol-associated developmental and presynaptic deficits

2022-12-29

Abstract excerpt

Amyloid precursor protein (APP) produces aggregable β-amyloid peptides and its mutations are associated with familial Alzheimer’s disease, which makes it one of the most studied proteins. However, APP’s role in the human brain remains unclear despite years of investigation. One problem is that most studies on APP have been carried out in cell lines or model organisms, which are physiologically different from human...

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Literature Corpus work: 9737cce4-d993-5152-9f8b-99b1c45da656
DOI: 10.1101/2022.12.28.522116

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