Article
Cellular functions of the amyloid precursor protein from development to dementia.
Developmental cell - 23 Feb 2015
van der Kant Rik, Goldstein Lawrence S B
Abstract excerpt
Amyloid precursor protein (APP) is a key player in Alzheimer's disease (AD). The Aβ fragments of APP are the major constituent of AD-associated amyloid plaques, and mutations or duplications of the gene coding for APP can cause familial AD. Here we review the roles of APP in neuronal development, signaling, intracellular transport, and other aspects of neuronal homeostasis. We suggest that APP acts as a signaling...
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