Article

Mutations in the juxtamembrane segment of the cholesterol-binding site of APP alter its processing and promotes production of shorter, less toxic Aβ peptides

2020-11-16

Abstract excerpt

<h4>Background</h4> The brains of patients with Alzheimer’s disease (AD) reveal increased cellular membrane levels of cholesterol. Correspondingly, we previously showed that elevating levels of membrane cholesterol in neuronal cultures recapitulates early AD phenotypes including excessive cleavage of amyloid β (Aβ) peptides from the amyloid precursor protein (APP). Here we aimed to evaluate how the presence of a...

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Literature Corpus work: b575545c-d4b4-55ce-ac4c-1297069e9cd6
DOI: 10.1101/2020.11.16.384891

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