Article

Single-cell splicing analysis with <i>ISSAC</i> links cell type-specific and cell state-dependent sQTLs to neurological disorders

2026-05-07

Abstract excerpt

Single-cell RNA sequencing enables comprehensive profiling of gene expression and splicing at cellular resolution, revealing cell type-specific and cell state-dependent regulation (variation within cell types based on their functional states). While genetic studies of expression (eQTLs) in single cells are well established, the genetic regulation of alternative splicing in single cells remains challenging. Existin...

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Literature Corpus work: c1732602-0ede-5217-bc57-7d1776ec6a28
DOI: 10.64898/2026.05.06.26352548

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