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Advancing Cell Therapies: Single-Cell Profiling, Generation, Expansion, and Gene Delivery in Rhesus Macaque Plasma B Cells

2023-11-01

Abstract excerpt

Engineered long lived plasma cells have the potential to be a new area of cell therapy. A key step in developing this cell therapy is testing in a model with an intact immune system similar to humans. To that end, we have developed methods to purify, expand, and differentiate non-human primate (NHP; rhesus macaque ) B cells ex vivo . We consistently achieved 10-fold expansion of NHP B cells using a readily avail...

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Literature Corpus work: 3c36b538-8926-5082-84b6-f7f788b36cba
DOI: 10.1101/2023.10.29.564645

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